Important application value of injectable hydrogels loaded with omeprazole Schiff base complex in the treatment of pancreatitis

Abstract

In this study, a novel Ho(iii) coordination complex with the chemical composition of [Ho6(acac)4L4(CH3O)6]·xCH3OH (1) has been prepared via using a polydentate Schiff base ligand N′-(2,3-dihydroxybenzylidene) picolinohydrazide (H2L) and a β-diketone (Hacac = acetylacetone) co-ligand, and then successfully loaded with drug omeprazole. Hyaluronic acid, a natural polysaccharide with good biocompatibility, was used as raw material to prepare drug carriers that can be injected into hydrogels based on chemical synthesis method. The internal microstructure of the hydrogel was observed by scanning electron microscope, which showed a good three-dimensional connected porous structure. After the synthesis of the hydrogel, the value of their application in the treatment of pancreatitis was evaluated and the related mechanisms were explored at the same time.

Keywords

• complex
• hydrogels
• omeprazole
• hyaluronic acid
• drug carriers