Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis

Athanasia Athanasaki; Konstantinos Melanis; Ioanna Tsantzali; Maria Ioanna Stefanou; Sofia Ntymenou; Sotirios G. Paraskevas; Theodosis Kalamatianos; Eleni Boutati; Vaia Lambadiari; Konstantinos I. Voumvourakis; George Stranjalis; Sotirios Giannopoulos; Georgios Tsivgoulis; George P. Paraskevas

doi:10.3390/biomedicines10040778

Biomedicines (Mar 2022)

Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis

Athanasia Athanasaki,
Konstantinos Melanis,
Ioanna Tsantzali,
Maria Ioanna Stefanou,
Sofia Ntymenou,
Sotirios G. Paraskevas,
Theodosis Kalamatianos,
Eleni Boutati,
Vaia Lambadiari,
Konstantinos I. Voumvourakis,
George Stranjalis,
Sotirios Giannopoulos,
Georgios Tsivgoulis,
George P. Paraskevas

Affiliations

Athanasia Athanasaki: Department of Neurology, Evangelismos Hospital, 10676 Athens, Greece
Konstantinos Melanis: 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece
Ioanna Tsantzali: 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece
Maria Ioanna Stefanou: 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece
Sofia Ntymenou: Department of Neurology, Evangelismos Hospital, 10676 Athens, Greece
Sotirios G. Paraskevas: 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece
Theodosis Kalamatianos: 1st Department of Neurosurgery, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, Greece
Eleni Boutati: 2nd Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece
Vaia Lambadiari: 2nd Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece
Konstantinos I. Voumvourakis: 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece
George Stranjalis: 1st Department of Neurosurgery, School of Medicine, National and Kapodistrian University of Athens, Evangelismos Hospital, 10676 Athens, Greece
Sotirios Giannopoulos: 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece
Georgios Tsivgoulis: 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece
George P. Paraskevas: 2nd Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University General Hospital, 12462 Athens, Greece

DOI: https://doi.org/10.3390/biomedicines10040778
Journal volume & issue: Vol. 10, no. 4
p. 778

Abstract

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Alzheimer’s disease is the most common type of dementia, reaching 60–80% of case totals, and is one of the major global causes of the elderly population’s decline in functionality concerning daily life activities. Epidemiological research has already indicated that, in addition to several others metabolic factors, diabetes mellitus type 2 is a risk factor of Alzheimer’s disease. Many molecular pathways have been described, and at the same time, there are clues that suggest the connection between type 2 diabetes mellitus and Alzheimer’s disease, through specific genes, autophagy, and even inflammatory pathways. A systematic review with meta-analysis was conducted, and its main goal was to reveal the multilevel connection between these diseases.

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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