Communications Biology (Dec 2022)

Axl receptor induces efferocytosis, dampens M1 macrophage responses and promotes heart pathology in Trypanosoma cruzi infection

  • Thaís S. Rigoni,
  • Natália S. Vellozo,
  • Kamila Guimarães-Pinto,
  • Mariela Cabral-Piccin,
  • Laryssa Fabiano-Coelho,
  • Thayane C. Matos-Silva,
  • Alessandra A. Filardy,
  • Christina M. Takiya,
  • Marcela F. Lopes

DOI
https://doi.org/10.1038/s42003-022-04401-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 16

Abstract

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The tyrosine kinase receptor Axl induces efferocytosis, disrupts M1 responses, and promotes parasite infection and heart pathology in experimental Chagas disease.