Shenqifuzheng injection inhibits lactic acid-induced cisplatin resistance in NSCLC by affecting FBXO22/p53 axis through FOXO3

Wei Bo; Xiaokai Wang; Ning Yu; Chun Wang; Chunying Liu

doi:10.1186/s12931-024-03013-8

Respiratory Research (Nov 2024)

Shenqifuzheng injection inhibits lactic acid-induced cisplatin resistance in NSCLC by affecting FBXO22/p53 axis through FOXO3

Wei Bo,
Xiaokai Wang,
Ning Yu,
Chun Wang,
Chunying Liu

Affiliations

Wei Bo: College of Integrated Chinese and Western Medical, Liaoning University of Traditional Chinese Medicine
Xiaokai Wang: Pathology Department, Shenyang Key Laboratory for Screening Biomarkers of Tumor Progression and Targeted Therapy of Tumors, Shenyang Medical College
Ning Yu: College of Integrated Chinese and Western Medical, Liaoning University of Traditional Chinese Medicine
Chun Wang: College of Integrated Chinese and Western Medical, Liaoning University of Traditional Chinese Medicine
Chunying Liu: College of Integrated Chinese and Western Medical, Liaoning University of Traditional Chinese Medicine

DOI: https://doi.org/10.1186/s12931-024-03013-8
Journal volume & issue: Vol. 25, no. 1
pp. 1 – 15

Abstract

Read online

Highlights FOXO3 was decreased, while LA and FBXO22 were increased in NSCLC patients. LA promoted cisplatin resistance in NSCLC in vitro and in vivo. SQFZ inhibited LA-induced cisplatin resistance in NSCLC by regulating FOXO3. FBXO22 affected p53 ubiquitination to reverse the inhibitory effect of SQFZ. SQFZ inhibited cisplatin resistance in NSCLC by FOXO3/FBXO22/p53 axis.

Published in Respiratory Research

ISSN: 1465-9921 (Print); 1465-993X (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: https://respiratory-research.biomedcentral.com/

About the journal

Abstract

Keywords