MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

Stephan Lange; Katja Gehmlich; Alexander S. Lun; Jordan Blondelle; Charlotte Hooper; Nancy D. Dalton; Erika A. Alvarez; Xiaoyu Zhang; Marie-Louise Bang; Yama A. Abassi; Cristobal G. dos Remedios; Kirk L. Peterson; Ju Chen; Elisabeth Ehler

doi:10.1038/ncomms12120

Nature Communications (Jun 2016)

MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy

Stephan Lange,
Katja Gehmlich,
Alexander S. Lun,
Jordan Blondelle,
Charlotte Hooper,
Nancy D. Dalton,
Erika A. Alvarez,
Xiaoyu Zhang,
Marie-Louise Bang,
Yama A. Abassi,
Cristobal G. dos Remedios,
Kirk L. Peterson,
Ju Chen,
Elisabeth Ehler

Affiliations

Stephan Lange: School of Medicine, University of California
Katja Gehmlich: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence Oxford, University of Oxford
Alexander S. Lun: School of Medicine, University of California
Jordan Blondelle: School of Medicine, University of California
Charlotte Hooper: Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence Oxford, University of Oxford
Nancy D. Dalton: School of Medicine, University of California
Erika A. Alvarez: School of Medicine, University of California
Xiaoyu Zhang: ACEA Biosciences
Marie-Louise Bang: Institute of Genetic and Biomedical Research, UOS Milan, National Research Council
Yama A. Abassi: ACEA Biosciences
Cristobal G. dos Remedios: Department of Anatomy, Bosch Institute, University of Sydney
Kirk L. Peterson: School of Medicine, University of California
Ju Chen: School of Medicine, University of California
Elisabeth Ehler: Cardiovascular Division and Randall Division of Cell and Molecular Biophysics, BHF Centre of Research Excellence at King’s College London

DOI: https://doi.org/10.1038/ncomms12120
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Altered function of the muscle LIM protein (MLP) causes dilated cardiomyopathy in mice and humans. Lange et al. explain the molecular role of MLP in the heart by showing that it affects the signalling complex at the intercalated discs of failing hearts that consists of PKCα, PLCβ1 and CARP by inhibiting PKCα auto-phosphorylation and function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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