Nature Communications (Jul 2017)
The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways
- Kun Zhang,
- Xiaohui Han,
- Zhen Zhang,
- Lina Zheng,
- Zhimei Hu,
- Qingbin Yao,
- Hongmei Cui,
- Guiming Shu,
- Maojie Si,
- Chan Li,
- Zhemin Shi,
- Ting Chen,
- Yawei Han,
- Yanan Chang,
- Zhi Yao,
- Tao Han,
- Wei Hong
Affiliations
- Kun Zhang
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Xiaohui Han
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Zhen Zhang
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Lina Zheng
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Zhimei Hu
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Qingbin Yao
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Hongmei Cui
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Guiming Shu
- The Third Central Clinical College of Tianjin Medical University, Tianjin Third Central Hospital
- Maojie Si
- The Third Central Clinical College of Tianjin Medical University, Tianjin Third Central Hospital
- Chan Li
- The Third Central Clinical College of Tianjin Medical University, Tianjin Third Central Hospital
- Zhemin Shi
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Ting Chen
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Yawei Han
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Yanan Chang
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- Zhi Yao
- Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Tao Han
- The Third Central Clinical College of Tianjin Medical University, Tianjin Third Central Hospital
- Wei Hong
- Department of Histology and Embryology, School of Basic Medical Sciences, Tianjin Medical University
- DOI
- https://doi.org/10.1038/s41467-017-00204-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Activated hepatic stellate cells are the principal contributors to liver fibrosis by secreting a variety of pro-fibrogenic cytokines . Here Zhang et al. demonstrate that a liver-enriched lncRNA, lnc-LFAR1, promotes liver fibrosis and HSC activation by activating TGFβ and Notch signaling.
