The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

Hye-Jin Boo; Hye-Young Min; Hyun-Ji Jang; Hye Jeong Yun; John Kendal Smith; Quanri Jin; Hyo-Jong Lee; Diane Liu; Hee-Seok Kweon; Carmen Behrens; J. Jack Lee; Ignacio I. Wistuba; Euni Lee; Waun Ki Hong; Ho-Young Lee

doi:10.1038/ncomms12961

Nature Communications (Sep 2016)

The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

Hye-Jin Boo,
Hye-Young Min,
Hyun-Ji Jang,
Hye Jeong Yun,
John Kendal Smith,
Quanri Jin,
Hyo-Jong Lee,
Diane Liu,
Hee-Seok Kweon,
Carmen Behrens,
J. Jack Lee,
Ignacio I. Wistuba,
Euni Lee,
Waun Ki Hong,
Ho-Young Lee

Affiliations

Hye-Jin Boo: Creative Research Initiative Center for Concurrent Control of Emphysema and Lung Cancer, College of Pharmacy, Seoul National University
Hye-Young Min: Creative Research Initiative Center for Concurrent Control of Emphysema and Lung Cancer, College of Pharmacy, Seoul National University
Hyun-Ji Jang: Creative Research Initiative Center for Concurrent Control of Emphysema and Lung Cancer, College of Pharmacy, Seoul National University
Hye Jeong Yun: Creative Research Initiative Center for Concurrent Control of Emphysema and Lung Cancer, College of Pharmacy, Seoul National University
John Kendal Smith: Departments of Thoracic/Head & Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center
Quanri Jin: Departments of Thoracic/Head & Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center
Hyo-Jong Lee: Departments of Thoracic/Head & Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center
Diane Liu: Department of Biostatics, The University of Texas M.D. Anderson Cancer Center
Hee-Seok Kweon: Division of Electron Microscopic Research, Korea Basic Science Institute
Carmen Behrens: Departments of Thoracic/Head & Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center
J. Jack Lee: Department of Biostatics, The University of Texas M.D. Anderson Cancer Center
Ignacio I. Wistuba: Departments of Thoracic/Head & Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center
Euni Lee: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University
Waun Ki Hong: Departments of Thoracic/Head & Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center
Ho-Young Lee: Creative Research Initiative Center for Concurrent Control of Emphysema and Lung Cancer, College of Pharmacy, Seoul National University

DOI: https://doi.org/10.1038/ncomms12961
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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The binding of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to nicotinic acetylcholine receptors (nAChRs) induces calcium signalling. Here the authors show that NKK-induced calcium influx in airway epithelial cells triggers IGF2 secretion and tumourigenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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