Nature Communications (Dec 2020)

Reverse C-glycosidase reaction provides C-nucleotide building blocks of xenobiotic nucleic acids

  • Martin Pfeiffer,
  • Bernd Nidetzky

DOI
https://doi.org/10.1038/s41467-020-20035-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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C-nucleosides are analogues of the canonical N-nucleosides and, despite their synthetic value, biocatalysis has not targeted them yet. Here, the authors report a pseudouridine monophosphate C-glycosidase enzyme for selective 5-β-C-glycosylation of uracil and its derivatives from pentose 5- phosphate substrates.