Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism

Abstract

Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems. Presently, the development mechanisms remain poorly understood despite the presence of the considered theories of DIP pathogenesis.

Keywords

• antipsychotic-induced parkinsonism
• drug-induced parkinsonism
• antipsychotics
• theories of pathogenesis
• pathophysiology
• pathogenesis