Nature Communications (Jul 2019)
The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression
- Hélène Lazareth,
- Carole Henique,
- Olivia Lenoir,
- Victor G. Puelles,
- Martin Flamant,
- Guillaume Bollée,
- Cécile Fligny,
- Marine Camus,
- Lea Guyonnet,
- Corinne Millien,
- François Gaillard,
- Anna Chipont,
- Blaise Robin,
- Sylvie Fabrega,
- Neeraj Dhaun,
- Eric Camerer,
- Oliver Kretz,
- Florian Grahammer,
- Fabian Braun,
- Tobias B. Huber,
- Dominique Nochy,
- Chantal Mandet,
- Patrick Bruneval,
- Laurent Mesnard,
- Eric Thervet,
- Alexandre Karras,
- François Le Naour,
- Eric Rubinstein,
- Claude Boucheix,
- Antigoni Alexandrou,
- Marcus J. Moeller,
- Cédric Bouzigues,
- Pierre-Louis Tharaux
Affiliations
- Hélène Lazareth
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Carole Henique
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Olivia Lenoir
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Victor G. Puelles
- Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen
- Martin Flamant
- Xavier Bichat University Hospital, Université de Paris
- Guillaume Bollée
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Cécile Fligny
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Marine Camus
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Lea Guyonnet
- National Cytometry Platform, Department of Infection and Immunity, Luxembourg Institute of Health
- Corinne Millien
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- François Gaillard
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Anna Chipont
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Blaise Robin
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Sylvie Fabrega
- Université de Paris, Institut Imagine, Plateforme Vecteurs Viraux et Transfert de Gènes, IFR94, Hôpital Necker Enfants-Malades
- Neeraj Dhaun
- Department of Renal Medicine, Royal Infirmary of Edinburgh
- Eric Camerer
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Oliver Kretz
- Department of Medicine III, Faculty of Medicine, University Medical Center Hamburg-Eppendorf
- Florian Grahammer
- Department of Medicine III, Faculty of Medicine, University Medical Center Hamburg-Eppendorf
- Fabian Braun
- Department of Medicine III, Faculty of Medicine, University Medical Center Hamburg-Eppendorf
- Tobias B. Huber
- Department of Medicine III, Faculty of Medicine, University Medical Center Hamburg-Eppendorf
- Dominique Nochy
- Department of Pathology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris
- Chantal Mandet
- Department of Pathology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris
- Patrick Bruneval
- Department of Pathology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris
- Laurent Mesnard
- Critical Care Nephrology and Kidney Transplantation, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Unité Mixte de Recherche S1155, Pierre and Marie Curie University
- Eric Thervet
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- Alexandre Karras
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- François Le Naour
- Inserm U1193, Université Paris-Sud
- Eric Rubinstein
- Inserm U935, Université Paris-Sud
- Claude Boucheix
- Inserm U935, Université Paris-Sud
- Antigoni Alexandrou
- Laboratoire d’Optique et Biosciences, Ecole polytechnique, CNRS UMR7645, INSERM U1182, Université Paris-Saclay
- Marcus J. Moeller
- Department of Nephrology and Clinical Immunology, University Hospital RWTH Aachen
- Cédric Bouzigues
- Laboratoire d’Optique et Biosciences, Ecole polytechnique, CNRS UMR7645, INSERM U1182, Université Paris-Saclay
- Pierre-Louis Tharaux
- Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 970, Paris Cardiovascular Center – PARCC
- DOI
- https://doi.org/10.1038/s41467-019-11013-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
In both focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN), kidney injury is characterised by the invasion of glomerular tufts by parietal epithelial cells (PECs). Here Lazareth et al. identify the tetraspanin CD9 as a key regulator of PEC migration, and find its upregulation in FSGS and CGN contributes to kidney injury in both diseases.
