Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues

• Jacynthe L. Toulouse,
• Brahm J. Yachnin,
• Edward H. Ruediger,
• Daniel Deon,
• Marc Gagnon,
• Kévin Saint-Jacques,
• Maximilian C. C. J. C. Ebert,
• Delphine Forge,
• Dominic Bastien,
• Damien Y. Colin,
• Jean Jacques Vanden Eynde,
• Anne Marinier,
• Albert M. Berghuis,
• Joelle N. Pelletier

Affiliations

Jacynthe L. Toulouse

†Département de Biochimie, Université de Montréal, Montreal, Quebec, Canada

Brahm J. Yachnin

PROTEO, the Québec Network for Research on Protein, Function, Engineering and Applications, Quebec, Canada

Edward H. Ruediger

⊥Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, Quebec, Canada

Daniel Deon

⊥Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, Quebec, Canada

Marc Gagnon

⊥Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, Quebec, Canada

Kévin Saint-Jacques

⊥Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, Quebec, Canada

Maximilian C. C. J. C. Ebert

Chemical Computing Group, Montreal, Quebec, Canada

Delphine Forge

Laboratoire de Chimie Organique, Université de Mons, Mons, Belgium

Dominic Bastien

†Département de Biochimie, Université de Montréal, Montreal, Quebec, Canada

Damien Y. Colin

PROTEO, the Québec Network for Research on Protein, Function, Engineering and Applications, Quebec, Canada

Jean Jacques Vanden Eynde

Laboratoire de Chimie Organique, Université de Mons, Mons, Belgium

Anne Marinier

⊥Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, Quebec, Canada

Albert M. Berghuis

PROTEO, the Québec Network for Research on Protein, Function, Engineering and Applications, Quebec, Canada

Joelle N. Pelletier

†Département de Biochimie, Université de Montréal, Montreal, Quebec, Canada