Stationary Distribution and Extinction of a Stochastic Viral Infection Model

Abstract

We present a kind of stochastic viral infection model with or without a loss term in the free virus equation. We obtain critical condition to ensure the existence of the unique stationary distribution by constructing Lyapunov functions. We also obtain the sufficient conditions for the extinction of the virus by the comparison theorem of stochastic differential equation and law of large numbers. We give a unified method to systematically analyze such three-dimensional stochastic viral infection model. Furthermore, numerical simulations are carried out to examine the effect of white noises on model behavior. We investigate the fact that the small magnitudes of white noises can sustain the irregular recurrence of healthy target cells and virions, while the big ones may contribute to viral clearance.