Hemiparetic Primary Lateral Sclerosis: Revisiting Mills Syndrome

Abstract

A slowly progressive hemiparesis beginning in a single limb with evolution to the ipsilateral limb was originally described in 8 patients in 1906 by Mills. We present 5 cases of progressive hemiparetic corticospinal tract degeneration, identified by the clinical presentation and the exclusion of other etiologies using serological, imaging, and electrodiagnostic studies.

Keywords

• Prognosis
• Primary lateral sclerosis
• Mills syndrome
• Asymmetry