Nature Communications (Dec 2022)
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance
- Alessandra Dall’Agnese,
- Jesse M. Platt,
- Ming M. Zheng,
- Max Friesen,
- Giuseppe Dall’Agnese,
- Alyssa M. Blaise,
- Jessica B. Spinelli,
- Jonathan E. Henninger,
- Erin N. Tevonian,
- Nancy M. Hannett,
- Charalampos Lazaris,
- Hannah K. Drescher,
- Lea M. Bartsch,
- Henry R. Kilgore,
- Rudolf Jaenisch,
- Linda G. Griffith,
- Ibrahim I. Cisse,
- Jacob F. Jeppesen,
- Tong I. Lee,
- Richard A. Young
Affiliations
- Alessandra Dall’Agnese
- Whitehead Institute for Biomedical Research
- Jesse M. Platt
- Whitehead Institute for Biomedical Research
- Ming M. Zheng
- Whitehead Institute for Biomedical Research
- Max Friesen
- Whitehead Institute for Biomedical Research
- Giuseppe Dall’Agnese
- Whitehead Institute for Biomedical Research
- Alyssa M. Blaise
- Whitehead Institute for Biomedical Research
- Jessica B. Spinelli
- Whitehead Institute for Biomedical Research
- Jonathan E. Henninger
- Whitehead Institute for Biomedical Research
- Erin N. Tevonian
- Department of Biological Engineering, Massachusetts Institute of Technology
- Nancy M. Hannett
- Whitehead Institute for Biomedical Research
- Charalampos Lazaris
- Whitehead Institute for Biomedical Research
- Hannah K. Drescher
- Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital
- Lea M. Bartsch
- Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital
- Henry R. Kilgore
- Whitehead Institute for Biomedical Research
- Rudolf Jaenisch
- Whitehead Institute for Biomedical Research
- Linda G. Griffith
- Department of Biological Engineering, Massachusetts Institute of Technology
- Ibrahim I. Cisse
- Department of Physics, Massachusetts Institute of Technology
- Jacob F. Jeppesen
- Whitehead Institute for Biomedical Research
- Tong I. Lee
- Whitehead Institute for Biomedical Research
- Richard A. Young
- Whitehead Institute for Biomedical Research
- DOI
- https://doi.org/10.1038/s41467-022-35176-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.
