2-Methoxyethanol as an alternative reaction solvent for the synthesis of 1,5-benzodiazepines under microwave irradiation

Abstract

An improved condensation reaction between substituted 2’-hydroxychalcones and o-phenylenediamine using piperidine in 2-methoxyetahnol as an efficient and alternative reaction medium. The clean reaction conditions, easy work up, time saving and higher yields are notable advantages of present method.

Keywords

• 2’-hydroxychalcones
• 2-methoxyethanol
• green chemistry
• microwave irradiation