Frontiers in Nutrition (Apr 2022)

Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study

  • Liqiang Zheng,
  • Liqiang Zheng,
  • Liqiang Zheng,
  • Yanxia Xie,
  • Zhaoqing Sun,
  • Rui Zhang,
  • Yanan Ma,
  • Yanan Ma,
  • Jiahui Xu,
  • Jiahui Xu,
  • Jia Zheng,
  • Jia Zheng,
  • Qianyi Xu,
  • Qianyi Xu,
  • Zhao Li,
  • Xiaofan Guo,
  • Guozhe Sun,
  • Fuguo Xing,
  • Yingxian Sun,
  • Deliang Wen

DOI
https://doi.org/10.3389/fnut.2022.843616
Journal volume & issue
Vol. 9

Abstract

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The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies. Using a nested case-control study, we estimated the association between serum spermidine level and future stroke. New stroke cases had higher baseline levels of spermidine than controls [182.8 (141.8–231.5) vs. 152.0 (124.3–193.0), P < 0.001]. After multivariable adjustment, individuals with spermidine ≥ 205.9 nmol/L (T3) higher risks of stroke (HR 5.02, 95% CI 1.58–16.02) with the lowest quartile (< 136.9 nmol/L) as reference. The association between serum spermidine levels and risk of stroke seemed to be consistent and was reproducible in our cross-sectional studies. In addition, comparisons of the areas under receiver operator characteristics curves confirmed that a model including spermidine had better discrimination than without (0.755 vs. 0.715, P = 0.04). Here we report a close relationship exists between serum spermidine levels and risk of stroke.

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