Orexin modulates behavioral fear expression through the locus coeruleus

Shingo Soya; Tohru M. Takahashi; Thomas J. McHugh; Takashi Maejima; Stefan Herlitze; Manabu Abe; Kenji Sakimura; Takeshi Sakurai

doi:10.1038/s41467-017-01782-z

Nature Communications (Nov 2017)

Orexin modulates behavioral fear expression through the locus coeruleus

Shingo Soya,
Tohru M. Takahashi,
Thomas J. McHugh,
Takashi Maejima,
Stefan Herlitze,
Manabu Abe,
Kenji Sakimura,
Takeshi Sakurai

Affiliations

Shingo Soya: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
Tohru M. Takahashi: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
Thomas J. McHugh: Laboratory for Circuit & Behavioral Physiology RIKEN Brain Science Institute, Wako
Takashi Maejima: Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Kanazawa
Stefan Herlitze: Department of General Zoology and Neurobiology, ND7/31, Ruhr-University Bochum
Manabu Abe: Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Asahimachi
Kenji Sakimura: Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Asahimachi
Takeshi Sakurai: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba

DOI: https://doi.org/10.1038/s41467-017-01782-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Vigilance involves the activation of orexinergic neurons in the lateral hypothalamus (LH-ox). Here the authors report the functional role of a monosynaptically connected circuit with orexinergic neurons connected to noradrenergic neurons in the locus coeruleus which target lateral amygdala neurons and enhance fear expression and generalization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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