Preclinical Assessment Addressing Intravenous Administration of a [⁶⁸Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution

Abstract

It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.

Keywords

• biodistribution
• ⁶⁸Ga
• [⁶⁸Ga]Ga-PSMA-617-ME
• in vivo
• microemulsion
• microPET/CT