DREAM: a database of experimentally supported protein-coding RNAs and drug associations in human cancer

Shupeng Li; Lulu Li; Xiangqi Meng; Penggang Sun; Yi Liu; Yuntang Song; Sijia Zhang; Chuanlu Jiang; Jinquan Cai; Zheng Zhao

doi:10.1186/s12943-021-01436-1

Molecular Cancer (Nov 2021)

DREAM: a database of experimentally supported protein-coding RNAs and drug associations in human cancer

Shupeng Li,
Lulu Li,
Xiangqi Meng,
Penggang Sun,
Yi Liu,
Yuntang Song,
Sijia Zhang,
Chuanlu Jiang,
Jinquan Cai,
Zheng Zhao

Affiliations

Shupeng Li: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Lulu Li: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Xiangqi Meng: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Penggang Sun: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Yi Liu: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Yuntang Song: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Sijia Zhang: Department of Educational Administration, the Second Affiliated Hospital of Harbin Medical University
Chuanlu Jiang: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Jinquan Cai: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Neuroscience Institute, Heilongjiang Academy of Medical Sciences
Zheng Zhao: Beijing Neurosurgical Institute, Capital Medical University

DOI: https://doi.org/10.1186/s12943-021-01436-1
Journal volume & issue: Vol. 20, no. 1
pp. 1 – 6

Abstract

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Abstract The Drug Response Gene Expression Associated Map, also referred as “DREAM” ( http://bio-big-data.cn:8080/DREAM ), is a manually curated database of experimentally supported protein-coding RNAs and drugs associations in human cancers. The current version of the DREAM documents 3048 entries about scientific literatures supported drug sensitivity or drug intervention related protein-coding RNAs from PubMed database and 195 high-throughput microarray data about drug sensitivity or drug intervention related protein-coding RNAs data from GEO database. Each entry in DREAM database contains detailed information on protein-coding RNA, drug, cancer, and other information including title, PubMed ID, journal, publish time. The DREAM database also provides some data visualization and online analysis services such as volcano plot, GO/KEGG enrichment function analysis, and novel drug discovery analysis. We hope the DREAM database should serve as a valuable resource for clinical practice and basic research, which could help researchers better understand the effects of protein-coding RNAs on drug response in human cancers.

Published in Molecular Cancer

ISSN: 1476-4598 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://molecular-cancer.biomedcentral.com/

About the journal

Abstract

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