Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath Govindarajan; Djoere Gaublomme; Renée Van der Cruyssen; Eveline Verheugen; Sofie Van Gassen; Yvan Saeys; Simon Tavernier; Takao Iwawaki; Yehudi Bloch; Savvas. N. Savvides; Bart N. Lambrecht; Sophie Janssens; Dirk Elewaut; Michael B. Drennan

doi:10.1038/s41467-018-07758-x

Nature Communications (Dec 2018)

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath Govindarajan,
Djoere Gaublomme,
Renée Van der Cruyssen,
Eveline Verheugen,
Sofie Van Gassen,
Yvan Saeys,
Simon Tavernier,
Takao Iwawaki,
Yehudi Bloch,
Savvas. N. Savvides,
Bart N. Lambrecht,
Sophie Janssens,
Dirk Elewaut,
Michael B. Drennan

Affiliations

Srinath Govindarajan: Unit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research
Djoere Gaublomme: Unit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research
Renée Van der Cruyssen: Unit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research
Eveline Verheugen: Unit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research
Sofie Van Gassen: Department of Applied Mathematics, Computer Science and Statistics, Ghent University
Yvan Saeys: Department of Applied Mathematics, Computer Science and Statistics, Ghent University
Simon Tavernier: Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research
Takao Iwawaki: Division of Cell Medicine, Department of Life Science, Medical Research Institute, Kanazawa Medical University
Yehudi Bloch: Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University
Savvas. N. Savvides: Unit for Structural Biology, Department of Biochemistry and Microbiology, Ghent University
Bart N. Lambrecht: Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research
Sophie Janssens: Laboratory of ER Stress and Inflammation, VIB Center for Inflammation Research
Dirk Elewaut: Unit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research
Michael B. Drennan: Unit for Molecular Immunology and Inflammation, VIB Center for Inflammation Research

DOI: https://doi.org/10.1038/s41467-018-07758-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

Invariant natural killer T (iNKT) cells rapidly enhance cytokine secretion and effector function following activation, but the underlying mechanism is still unclear. Here the authors show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α, activates the p38 kinase to stabilize cytokine mRNA for enhanced iNKT functions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal