Nature Communications (May 2018)
STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion
- Jung-Mao Hsu,
- Weiya Xia,
- Yi-Hsin Hsu,
- Li-Chuan Chan,
- Wen-Hsuan Yu,
- Jong-Ho Cha,
- Chun-Te Chen,
- Hsin-Wei Liao,
- Chu-Wei Kuo,
- Kay-Hooi Khoo,
- Jennifer L. Hsu,
- Chia-Wei Li,
- Seung-Oe Lim,
- Shih-Shin Chang,
- Yi-Chun Chen,
- Guo-xin Ren,
- Mien-Chie Hung
Affiliations
- Jung-Mao Hsu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Weiya Xia
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yi-Hsin Hsu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Li-Chuan Chan
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Wen-Hsuan Yu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jong-Ho Cha
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Chun-Te Chen
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Hsin-Wei Liao
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Chu-Wei Kuo
- Institute of Biological Chemistry, Academia Sinica
- Kay-Hooi Khoo
- Institute of Biological Chemistry, Academia Sinica
- Jennifer L. Hsu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Chia-Wei Li
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Seung-Oe Lim
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Shih-Shin Chang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yi-Chun Chen
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Guo-xin Ren
- Department of Oral and Maxillofacial, Head and Neck Oncology, Affiliated 9th People’s Hospital, School of Medicine, Shanghai Jiaotong University
- Mien-Chie Hung
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-04313-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
PD-L1 accumulates on cancer stem cells and favours immune evasion but the mechanism underlying this accumulation are unknown. Here the authors show that epithelial-mesenchymal transition induces glycosylation and stabilisation of PD-L1; antagonising this process renders cancer cells sensitive to anti-Tim3-therapy.
