Iterative protecting group-free cross-coupling leading to chiral multiply arylated structures

Cathleen M. Crudden; Christopher Ziebenhaus; Jason P. G. Rygus; Kazem Ghozati; Phillip J. Unsworth; Masakazu Nambo; Samantha Voth; Marieke Hutchinson; Veronique S. Laberge; Yuuki Maekawa; Daisuke Imao

doi:10.1038/ncomms11065

Nature Communications (Apr 2016)

Iterative protecting group-free cross-coupling leading to chiral multiply arylated structures

Cathleen M. Crudden,
Christopher Ziebenhaus,
Jason P. G. Rygus,
Kazem Ghozati,
Phillip J. Unsworth,
Masakazu Nambo,
Samantha Voth,
Marieke Hutchinson,
Veronique S. Laberge,
Yuuki Maekawa,
Daisuke Imao

Affiliations

Cathleen M. Crudden: Department of Chemistry, Queen’s University, Chernoff Hall
Christopher Ziebenhaus: Department of Chemistry, Queen’s University, Chernoff Hall
Jason P. G. Rygus: Department of Chemistry, Queen’s University, Chernoff Hall
Kazem Ghozati: Department of Chemistry, Queen’s University, Chernoff Hall
Phillip J. Unsworth: Department of Chemistry, Queen’s University, Chernoff Hall
Masakazu Nambo: Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University
Samantha Voth: Department of Chemistry, Queen’s University, Chernoff Hall
Marieke Hutchinson: Department of Chemistry, Queen’s University, Chernoff Hall
Veronique S. Laberge: Department of Chemistry, Queen’s University, Chernoff Hall
Yuuki Maekawa: Department of Chemistry, Queen’s University, Chernoff Hall
Daisuke Imao: Department of Chemistry, Queen’s University, Chernoff Hall

DOI: https://doi.org/10.1038/ncomms11065
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 7

Abstract

Read online

The Suzuki-Miyaura cross coupling is widely used in industrial and academic settings for the formation of carbon-carbon bonds. Here, the authors report a procedure whereby a molecule with multiple reactive carbon-boron bonds can undergo sequential, selective Suzuki-Miyaura reactions without the need for protecting groups.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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