Nature Communications (Jul 2020)
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
- Charles P. Couturier,
- Shamini Ayyadhury,
- Phuong U. Le,
- Javad Nadaf,
- Jean Monlong,
- Gabriele Riva,
- Redouane Allache,
- Salma Baig,
- Xiaohua Yan,
- Mathieu Bourgey,
- Changseok Lee,
- Yu Chang David Wang,
- V. Wee Yong,
- Marie-Christine Guiot,
- Hamed Najafabadi,
- Bratislav Misic,
- Jack Antel,
- Guillaume Bourque,
- Jiannis Ragoussis,
- Kevin Petrecca
Affiliations
- Charles P. Couturier
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Shamini Ayyadhury
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Phuong U. Le
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Javad Nadaf
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Jean Monlong
- Department of Human Genetics, McGill University
- Gabriele Riva
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Redouane Allache
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Salma Baig
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Xiaohua Yan
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Mathieu Bourgey
- Department of Human Genetics, McGill University
- Changseok Lee
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Yu Chang David Wang
- Department of Human Genetics, McGill University
- V. Wee Yong
- Department of Clinical Neurosciences, University of Calgary
- Marie-Christine Guiot
- Department of Neuropathology, Montreal Neurological Institute and Hospital, McGill University
- Hamed Najafabadi
- Department of Human Genetics, McGill University
- Bratislav Misic
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Jack Antel
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- Guillaume Bourque
- Department of Human Genetics, McGill University
- Jiannis Ragoussis
- Department of Human Genetics, McGill University
- Kevin Petrecca
- Department of Neurosciences, Montreal Neurological Institute-Hospital, McGill University
- DOI
- https://doi.org/10.1038/s41467-020-17186-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
Glioblastoma is thought to arise from neural stem cells. Here, to investigate this, the authors use single-cell RNA-sequencing to compare glioblastoma to the fetal human brain, and find a similarity between glial progenitor cells and a subpopulation of glioblastoma cells.
