Nature Communications (Nov 2017)
Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells
- Tatsuyuki Matsudaira,
- Kojiro Mukai,
- Taishin Noguchi,
- Junya Hasegawa,
- Tomohisa Hatta,
- Shun-ichiro Iemura,
- Tohru Natsume,
- Norio Miyamura,
- Hiroshi Nishina,
- Jun Nakayama,
- Kentaro Semba,
- Takuya Tomita,
- Shigeo Murata,
- Hiroyuki Arai,
- Tomohiko Taguchi
Affiliations
- Tatsuyuki Matsudaira
- Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
- Kojiro Mukai
- Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
- Taishin Noguchi
- Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
- Junya Hasegawa
- Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
- Tomohisa Hatta
- Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology
- Shun-ichiro Iemura
- Medical Industry Translational Research Center, Fukushima Medical University
- Tohru Natsume
- Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology
- Norio Miyamura
- Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University
- Hiroshi Nishina
- Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University
- Jun Nakayama
- Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University
- Kentaro Semba
- Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University
- Takuya Tomita
- Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Shigeo Murata
- Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Hiroyuki Arai
- Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
- Tomohiko Taguchi
- Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-017-01255-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Yes-associated protein (YAP) is a growth-promoting transcription co-activator that regulates the malignancy of various cancers, however its regulation is not fully understood. Here the authors show that phosphatdylserine at recycling endosomes regulates YAP signalling pathway.
