Journal of Ophthalmic Inflammation and Infection (Nov 2022)

Post-traumatic endophthalmitis prophylaxis: a systematic review and meta-analysis

  • Joshua M. Van Swol,
  • Walter K. Myers,
  • Jonathan A. Beall,
  • Miriam M. Atteya,
  • Jeffrey P. Blice

DOI
https://doi.org/10.1186/s12348-022-00317-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Abstract Purpose The goal of this study is to determine if certain aspects of endophthalmitis prophylaxis strategies are superior to others. Design This investigation is a systematic review and meta-analysis. Methods All studies specifying a type of prophylaxis strategy and resulting rates of endophthalmitis were included. Time course, method of administration, and antibiotic regimen, and confounding factors were collected and included for meta-regression. Results Time courses greater than 24 h did not significantly improve outcomes. Likewise, intraocular and/or intravenous antibiotic administration methods did not significantly outperform oral administration. No antibiotic regimens performed differently from vancomycin/ ≥ 3rd generation cephalosporin except for ciprofloxacin monotherapy which yielded significantly worse outcomes. Conclusions Future antibiotic strategies should strongly consider the risks of antibiotic treatment > 24 h and administration methods other than the oral antibiotic forms. In addition, providers should be wary of using ciprofloxacin monotherapy for endophthalmitis prophylaxis when treating open globe injuries.

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