PARP1 inhibition elicits immune responses against non-small cell lung cancer

Abstract

High levels of intracellular poly(ADP-ribose) (PAR) resulting from an elevated activity of PAR polymerase-1 (PARP1) correlate with poor infiltration of non-small cell lung cancers by cytotoxic T lymphocytes and dismal patient prognosis. Preclinical experimentation now demonstrates that PARP1 inhibition in cancer cells mediates strong immunostimulatory effects.

Keywords

• Anticancer immune response
• metabolism
• tumor microenvironment
• immune escape
• non-small cell lung cancer