Dynamics of cytokine profile in patients with abdominal sepsis caused by pancreonecrosis

Abstract

Acute pancreatitis is one of the most pressing problems of modern pancreatology, according to the authors ranks first among surgical pathologies.The aim of this study was to evaluate the dynamics of cytokine profile in patients with abdominal sepsis caused by pancreatic necrosis.Materials and methods.The study was conducted in 12 patients diagnosed with abdominal sepsis caused by pancreatic necrosis, in the period from 2017 to 2020 who were treated in medical hospitals in Chernivtsi and Ternopil. The control group consisted of 17 patients without signs of abdominal sepsis and acute surgical pathology. Both groups were representative by age, sex, comorbidities, risk factors. Determination of experimental parameters in the blood of patients was performed in the postoperative period (the results were evaluated before surgery, on the first and tenth days of the postoperative period).Research results and their discussion.In patients with abdominal sepsis, a violation of the mechanisms of cell adhesion and costimulatory-cooperative interaction of immunocompetent cells was observed in the preoperative period, as indicated by the low level of CD11a + and CD162 + expression on them. The decrease in the content of IL-6 in the blood with a slight progressive increase in the level of IL-4 corresponds to a moderate imbalance of cytokine regulation of the immune response.

Keywords

• sepsis
• cytokines
• pancreatic necrosis