Genotyping cognate Plasmodium falciparum in humans and mosquitoes to estimate onward transmission of asymptomatic infections

Kelsey M. Sumner; Elizabeth Freedman; Lucy Abel; Andrew Obala; Brian W. Pence; Amy Wesolowski; Steven R. Meshnick; Wendy Prudhomme-O’Meara; Steve M. Taylor

doi:10.1038/s41467-021-21269-2

Nature Communications (Feb 2021)

Genotyping cognate Plasmodium falciparum in humans and mosquitoes to estimate onward transmission of asymptomatic infections

Kelsey M. Sumner,
Elizabeth Freedman,
Lucy Abel,
Andrew Obala,
Brian W. Pence,
Amy Wesolowski,
Steven R. Meshnick,
Wendy Prudhomme-O’Meara,
Steve M. Taylor

Affiliations

Kelsey M. Sumner: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
Elizabeth Freedman: Division of Infectious Diseases, School of Medicine, Duke University
Lucy Abel: Academic Model Providing Access to Healthcare, Moi Teaching and Referral Hospital
Andrew Obala: School of Medicine, College of Health Sciences, Moi University
Brian W. Pence: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
Amy Wesolowski: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
Steven R. Meshnick: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
Wendy Prudhomme-O’Meara: Division of Infectious Diseases, School of Medicine, Duke University
Steve M. Taylor: Division of Infectious Diseases, School of Medicine, Duke University

DOI: https://doi.org/10.1038/s41467-021-21269-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Asymptomatic malaria infections contribute to transmission. Here, Sumner et al. infer participant-to-mosquito transmission by sampling naturally-fed mosquitoes from households in Western Kenya and find that asymptomatic infections more than double the odds of transmission to a mosquito compared to symptomatic infections.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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