The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

Hyeyoun Chang; Zhenying Cai; Thomas  M. Roberts

doi:10.3390/biom9110713

Biomolecules (Nov 2019)

The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

Hyeyoun Chang,
Zhenying Cai,
Thomas M. Roberts

Affiliations

Hyeyoun Chang: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Zhenying Cai: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Thomas M. Roberts: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA

DOI: https://doi.org/10.3390/biom9110713
Journal volume & issue: Vol. 9, no. 11
p. 713

Abstract

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In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches for patients with PTEN-null tumors.

Published in Biomolecules

ISSN: 2218-273X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: https://www.mdpi.com/journal/biomolecules

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Abstract

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