A retrospective observation of virologically suppressed people living with HIV by comparing switching to BIC/TAF/FTC with initial use BIC/TAF/FTC

Abstract

AbstractBackground The objective of this study was to observe retrospectively the clinical response of virologically suppressed people living with HIV (PLWH) by comparing switching to BIC/TAF/FTC with initial use BIC/TAF/FTC.Methods PLWH using BIC/TAF/FTC was divided into ‘initial use’ group and ‘switching to’ group. Immune response, metabolic parameters and renal function between the two groups were analysed.Results The CD4 cell counts was higher in post- treatment than pre- treatment in the ‘switching to’ group (416.54 ± 212.11 cells/mm3 vs. 243.72 ± 156.64 cells/mm3, p < .001); however, significant differences were not observed in the ‘initial use’ group (p = .658). The effect of BIC/TAF/FTC on metabolism was not obvious. Serum creatinine (SCr) was improved in post-treatment than in pre-treatment in ‘switching to’ group (69.03 ± 18.78 vs. 77.52 ± 20.18, p < .001). Platelet count was lower in post-treatment than pre-treatment both in the ‘initial use’ group (175.81 ± 69.27 vs. 202.90 ± 66.56, p = .070) and in the ‘switching to’ group (177.04 ± 64.48 vs. 212.53 ± 63.43, p < .001).Conclusions ‘Switching to’ is superior to ‘initial use’ BIC/TAF/FTC in immune response among PLWH. The effect of BIC/TAF/FTC on metabolism is not obvious. BIC/TAF/FTC related thrombocytopenia needs to be further explored.

Keywords

• BIC/TAF/FTC
• clinical response
• initial use
• people living with HIV
• switching to