Recent advances and possibilities for the use of plant phenolic compounds to manage ageing-related diseases

Henrique Silvano Arruda; Iramaia Angelica Neri-Numa; Larissa Akemi Kido; Mário Roberto Maróstica Júnior; Glaucia Maria Pastore

Journal of Functional Foods (Dec 2020)

Recent advances and possibilities for the use of plant phenolic compounds to manage ageing-related diseases

Henrique Silvano Arruda,
Iramaia Angelica Neri-Numa,
Larissa Akemi Kido,
Mário Roberto Maróstica Júnior,
Glaucia Maria Pastore

Affiliations

Henrique Silvano Arruda: Bioflavors and Bioactive Compounds Laboratory, Department of Food Science, School of Food Engineering, University of Campinas, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo, Brazil; Nutrition and Metabolism Laboratory, Department of Food and Nutrition, School of Food Engineering, University of Campinas, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo, Brazil; Corresponding authors at: School of Food Engineering, University of Campinas, Monteiro Lobato Street 80, Campinas 13083-862, São Paulo, Brazil.
Iramaia Angelica Neri-Numa: Bioflavors and Bioactive Compounds Laboratory, Department of Food Science, School of Food Engineering, University of Campinas, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo, Brazil
Larissa Akemi Kido: Nutrition and Metabolism Laboratory, Department of Food and Nutrition, School of Food Engineering, University of Campinas, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo, Brazil; Biology of Reproduction Laboratory, Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Bertrand Russel Avenue s/n, 13083-865 Campinas, São Paulo, Brazil
Mário Roberto Maróstica Júnior: Nutrition and Metabolism Laboratory, Department of Food and Nutrition, School of Food Engineering, University of Campinas, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo, Brazil
Glaucia Maria Pastore: Bioflavors and Bioactive Compounds Laboratory, Department of Food Science, School of Food Engineering, University of Campinas, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo, Brazil; Corresponding authors at: School of Food Engineering, University of Campinas, Monteiro Lobato Street 80, Campinas 13083-862, São Paulo, Brazil.

Journal volume & issue: Vol. 75
p. 104203

Abstract

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Ageing is an emerging global public health concern due to the increasing number of elderly people and ageing-related degenerative disorders. Given the absence of effective treatments to manage ageing-related diseases, increasing efforts have been directed to find ways to reduce the risk of developing these disorders. Among them, plant phytochemicals, such as phenolic compounds, are considered potential anti-ageing agents due to their multifaceted biochemical actions. In this review, we focus on presenting the results of the last few years and pioneer researches mainly with animal models and human trials showing the key role of phenolic compounds as potential anti-ageing agents. Recent advances demonstrated that several phenolic compounds can reduce the risk and/or delay ageing-related disorders, including neurodegenerative diseases, metabolic syndromes, and cancers particularly by modulating signalling pathways involved in inflammation, oxidative damage, autophagy, and apoptosis. Therefore, plant phenolic compounds can be a complementary and alternative tool for managing ageing-related diseases.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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