Blood concentrations of endothelin, interleukins 6 and 10 in men with diabetes mellitus

Abstract

Background. Pathological activation of cytokines is one of the key links in the pathogenesis of diabetes mellitus (DM) and the development of its complications, in particular from the cardiovascular system. According to the vast majority of researchers, the imbalance of pro- and anti-inflammatory cytokines in patients with diabetes mellitus is a significant risk factor for mortality from cardiovascular disease. The purpose of the study was to determine the concentration of markers of a nonspecific inflammatory response (interleukin (IL) 6 and IL-10) in the blood of men with DM and their association with glycated hemoglobin levels and body mass index. Materials and methods. There were examined 46 men with type 2 DM and 28 men with type 1 DM. According to the results of the analysis of variance of the control group, type 2 DM and type 1 DM had significant differences in some indicators. Results. The correlation analysis of the obtained indicators of interleukin concentration showed that in men with type 2 DM under the age of 50 years, the indicators of IL-6 concentration significantly positively correlated with indicators of IL-10 concentration in blood (Spearman’s correlation coefficient 0.562, p < 0.031) and negatively with the duration of diabetes mellitus (Spearman’s correlation coefficient –0.508, p < 0.031). In the group of patients with type 2 DM aged 50 years and older, there was a positive correlation between the blood concentration of IL-6 with the blood concentration of IL-10 (Spearman’s correlation coefficient 0.509, p < 0.031), the blood concentration of IL-10 with glycated hemoglobin levels (Spearman’s correlation coefficient 0.391, p < 0.04) and the duration of diabetes mellitus (Spearman’s correlation coefficient 0.551, p < 0.005). In the group of patients with type 1 DM, there was a positive correlation of IL-6 in the blood with indicators of the blood concentration of IL-10 (Spearman’s correlation coefficient 0.707, p < 0.001) and a positive correlation between the concentration of IL-10 with the duration of DM (Spearman’s correlation coefficient 0.379, p < 0.039). Conclusions. Mean levels of IL-6 were significantly elevated in men with type 2 diabetes aged 50 years and older. Mean IL-10 levels were significantly elevated in men with type 2 diabetes regardless of the age of the patients. A significant positive correlation was found between the indicators of IL-6 and IL-10 in the examined patients with type 2 diabetes regardless of age also in patients with type 1 diabetes mellitus.

Keywords

• interleukin 10, interleukin 6, endothelin, diabetes mellitus