Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

Jian-Xin Lin; Ning Du; Peng Li; Majid Kazemian; Tesfay Gebregiorgis; Rosanne Spolski; Warren J. Leonard

doi:10.1038/s41467-017-01477-5

Nature Communications (Nov 2017)

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

Jian-Xin Lin,
Ning Du,
Peng Li,
Majid Kazemian,
Tesfay Gebregiorgis,
Rosanne Spolski,
Warren J. Leonard

Affiliations

Jian-Xin Lin: Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Ning Du: Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Peng Li: Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Majid Kazemian: Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Tesfay Gebregiorgis: Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Rosanne Spolski: Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
Warren J. Leonard: Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health

DOI: https://doi.org/10.1038/s41467-017-01477-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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IL-15 signals through STAT5 to modulate natural killer (NK) cell maturation, function and homeostasis, but the specific contributions of STAT5 dimers and tetramers are still unclear. Here the authors show that, while STAT5 dimers are sufficient for NK development, STAT5 tetramers are essential for NK homoeostasis by modulating apoptosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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