PLoS ONE (Jan 2015)

Use of PCR Signal and Therapeutic Drug Monitoring in a Switch Cohort Study to Tenofovir/Emtricitabine/Rilpivirine: A W96 Follow-Up.

  • Charlotte Charpentier,
  • Minh Patrick Lê,
  • Véronique Joly,
  • Benoit Visseaux,
  • Sylvie Lariven,
  • Bao Phung,
  • Patrick Yéni,
  • Yazdan Yazdanpanah,
  • Diane Descamps,
  • Gilles Peytavin,
  • Roland Landman

DOI
https://doi.org/10.1371/journal.pone.0134430
Journal volume & issue
Vol. 10, no. 7
p. e0134430

Abstract

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To assess, in a clinical cohort, the efficacy of switching treatment in virologically-suppressed patients to tenofovir/emtricitabine/rilpivirine as a single-tablet regimen (STR) using the PCR signal of the viral load (VL) assay and plasma drug determination (C24h).An observational single-centre study enrolling patients with VL50 ng/mL, the target effective concentration.In this clinical cohort of virologically-suppressed patients switching to a new STR, most subjects had adequate rilpivirine C24h and displayed a high level of virological suppression with no residual viremia until W96.