Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides

Mengmeng Wang; Jing-Xiang Wu; Dian Ding; Lei Chen

doi:10.1038/s41467-022-30430-4

Nature Communications (May 2022)

Structural insights into the mechanism of pancreatic KATP channel regulation by nucleotides

Mengmeng Wang,
Jing-Xiang Wu,
Dian Ding,
Lei Chen

Affiliations

Mengmeng Wang: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine
Jing-Xiang Wu: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine
Dian Ding: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine
Lei Chen: State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine

DOI: https://doi.org/10.1038/s41467-022-30430-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

KATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic KATP in both the closed state and the pre-open state. These structures illuminate the mechanism of KATP channel regulation by the intracellular nucleotides.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal