Nature Communications (Oct 2022)
Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs
- Wenxia Wang,
- Swarna Bale,
- Jun Wei,
- Bharath Yalavarthi,
- Dibyendu Bhattacharyya,
- Jing Jing Yan,
- Hiam Abdala-Valencia,
- Dan Xu,
- Hanshi Sun,
- Roberta G. Marangoni,
- Erica Herzog,
- Sergejs Berdnikovs,
- Stephen D. Miller,
- Amr H. Sawalha,
- Pei-Suen Tsou,
- Kentaro Awaji,
- Takashi Yamashita,
- Shinichi Sato,
- Yoshihide Asano,
- Chinnaswamy Tiruppathi,
- Anjana Yeldandi,
- Bettina C. Schock,
- Swati Bhattacharyya,
- John Varga
Affiliations
- Wenxia Wang
- Northwestern Scleroderma Program, Department of Medicine, Feinberg School of Medicine
- Swarna Bale
- Northwestern Scleroderma Program, Department of Medicine, Feinberg School of Medicine
- Jun Wei
- Northwestern Scleroderma Program, Department of Medicine, Feinberg School of Medicine
- Bharath Yalavarthi
- Michigan Scleroderma Program, Department of Internal Medicine, University of Michigan
- Dibyendu Bhattacharyya
- Michigan Scleroderma Program, Department of Internal Medicine, University of Michigan
- Jing Jing Yan
- Northwestern Scleroderma Program, Department of Medicine, Feinberg School of Medicine
- Hiam Abdala-Valencia
- Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
- Dan Xu
- Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine
- Hanshi Sun
- Michigan Scleroderma Program, Department of Internal Medicine, University of Michigan
- Roberta G. Marangoni
- Northwestern Scleroderma Program, Department of Medicine, Feinberg School of Medicine
- Erica Herzog
- Department of Medicine, Yale University School of Medicine
- Sergejs Berdnikovs
- Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine
- Stephen D. Miller
- Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine
- Amr H. Sawalha
- Department of Medicine, University of Pittsburgh School of Medicine
- Pei-Suen Tsou
- Michigan Scleroderma Program, Department of Internal Medicine, University of Michigan
- Kentaro Awaji
- Department of Dermatology, University of Tokyo Graduate School of Medicine
- Takashi Yamashita
- Department of Dermatology, University of Tokyo Graduate School of Medicine
- Shinichi Sato
- Department of Dermatology, University of Tokyo Graduate School of Medicine
- Yoshihide Asano
- Department of Dermatology, University of Tokyo Graduate School of Medicine
- Chinnaswamy Tiruppathi
- Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois
- Anjana Yeldandi
- Department of Pathology, Feinberg School of Medicine, Northwestern University
- Bettina C. Schock
- Wellcome-Wolfson Institute for Experimental Medicine, Queens University Belfast
- Swati Bhattacharyya
- Northwestern Scleroderma Program, Department of Medicine, Feinberg School of Medicine
- John Varga
- Northwestern Scleroderma Program, Department of Medicine, Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33767-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
A20 gene variants are linked with systemic sclerosis (SS), but the mechanisms are unclear. Here, the authors show that A20 expression is reduced in SS skin and lungs, that its ablation in mice induces SS, and that show that fibrosis can be ameliorated by induction of A20.
