Nature Communications (Apr 2021)
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein
- Ming Zhao,
- Yu Yu,
- Li-Ming Sun,
- Jia-Qing Xing,
- Tingting Li,
- Yunkai Zhu,
- Miao Wang,
- Yin Yu,
- Wen Xue,
- Tian Xia,
- Hong Cai,
- Qiu-Ying Han,
- Xiaoyao Yin,
- Wei-Hua Li,
- Ai-Ling Li,
- Jiuwei Cui,
- Zhenghong Yuan,
- Rong Zhang,
- Tao Zhou,
- Xue-Min Zhang,
- Tao Li
Affiliations
- Ming Zhao
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Yu Yu
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Li-Ming Sun
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Jia-Qing Xing
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Tingting Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Yunkai Zhu
- School of Basic Medical Sciences, Fudan University
- Miao Wang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Yin Yu
- School of Basic Medical Sciences, Fudan University
- Wen Xue
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Tian Xia
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Hong Cai
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Qiu-Ying Han
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Xiaoyao Yin
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Wei-Hua Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Ai-Ling Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Jiuwei Cui
- Cancer Research Institute of Jilin University, The First Hospital of Jilin University
- Zhenghong Yuan
- School of Basic Medical Sciences, Fudan University
- Rong Zhang
- School of Basic Medical Sciences, Fudan University
- Tao Zhou
- Nanhu Laboratory
- Xue-Min Zhang
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- Tao Li
- State Key Laboratory of Proteomics, National Center of Biomedical Analysis
- DOI
- https://doi.org/10.1038/s41467-021-22297-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Coronavirus nucleocapsid (N) protein is important for viral genome packaging and virion assembly. Here the authors show that natural chemical (-)-gallocatechin gallate (GCG) disrupts the liquid–liquid phase separation of N and inhibits SARS-CoV-2 replication.
