Nature Communications (Jun 2021)
Drug repurposing screens identify chemical entities for the development of COVID-19 interventions
- Malina A. Bakowski,
- Nathan Beutler,
- Karen C. Wolff,
- Melanie G. Kirkpatrick,
- Emily Chen,
- Tu-Trinh H. Nguyen,
- Laura Riva,
- Namir Shaabani,
- Mara Parren,
- James Ricketts,
- Anil K. Gupta,
- Kastin Pan,
- Peiting Kuo,
- MacKenzie Fuller,
- Elijah Garcia,
- John R. Teijaro,
- Linlin Yang,
- Debashis Sahoo,
- Victor Chi,
- Edward Huang,
- Natalia Vargas,
- Amanda J. Roberts,
- Soumita Das,
- Pradipta Ghosh,
- Ashley K. Woods,
- Sean B. Joseph,
- Mitchell V. Hull,
- Peter G. Schultz,
- Dennis R. Burton,
- Arnab K. Chatterjee,
- Case W. McNamara,
- Thomas F. Rogers
Affiliations
- Malina A. Bakowski
- Calibr, a division of The Scripps Research Institute
- Nathan Beutler
- Department of Immunology and Microbiology, The Scripps Research Institute
- Karen C. Wolff
- Calibr, a division of The Scripps Research Institute
- Melanie G. Kirkpatrick
- Calibr, a division of The Scripps Research Institute
- Emily Chen
- Calibr, a division of The Scripps Research Institute
- Tu-Trinh H. Nguyen
- Calibr, a division of The Scripps Research Institute
- Laura Riva
- Calibr, a division of The Scripps Research Institute
- Namir Shaabani
- Department of Immunology and Microbiology, The Scripps Research Institute
- Mara Parren
- Department of Immunology and Microbiology, The Scripps Research Institute
- James Ricketts
- Department of Immunology and Microbiology, The Scripps Research Institute
- Anil K. Gupta
- Calibr, a division of The Scripps Research Institute
- Kastin Pan
- Calibr, a division of The Scripps Research Institute
- Peiting Kuo
- Calibr, a division of The Scripps Research Institute
- MacKenzie Fuller
- Department of Cellular and Molecular Medicine, UC San Diego
- Elijah Garcia
- Department of Immunology and Microbiology, The Scripps Research Institute
- John R. Teijaro
- Department of Immunology and Microbiology, The Scripps Research Institute
- Linlin Yang
- Department of Immunology and Microbiology, The Scripps Research Institute
- Debashis Sahoo
- Department of Computer Science and Engineering, Jacobs School of Engineering, UC San Diego
- Victor Chi
- Calibr, a division of The Scripps Research Institute
- Edward Huang
- Calibr, a division of The Scripps Research Institute
- Natalia Vargas
- Calibr, a division of The Scripps Research Institute
- Amanda J. Roberts
- Animal Models Core Facility, The Scripps Research Institute
- Soumita Das
- HUMANOID CoRE, UC San Diego
- Pradipta Ghosh
- Department of Cellular and Molecular Medicine, UC San Diego
- Ashley K. Woods
- Calibr, a division of The Scripps Research Institute
- Sean B. Joseph
- Calibr, a division of The Scripps Research Institute
- Mitchell V. Hull
- Calibr, a division of The Scripps Research Institute
- Peter G. Schultz
- Calibr, a division of The Scripps Research Institute
- Dennis R. Burton
- Department of Immunology and Microbiology, The Scripps Research Institute
- Arnab K. Chatterjee
- Calibr, a division of The Scripps Research Institute
- Case W. McNamara
- Calibr, a division of The Scripps Research Institute
- Thomas F. Rogers
- Department of Immunology and Microbiology, The Scripps Research Institute
- DOI
- https://doi.org/10.1038/s41467-021-23328-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.
