Nature Communications (Dec 2016)
SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization
- Nkerorema Djodji Damas,
- Michela Marcatti,
- Christophe Côme,
- Lise Lotte Christensen,
- Morten Muhlig Nielsen,
- Roland Baumgartner,
- Helene Maria Gylling,
- Giulia Maglieri,
- Carsten Friis Rundsten,
- Stefan E. Seemann,
- Nicolas Rapin,
- Simon Thézenas,
- Søren Vang,
- Torben Ørntoft,
- Claus Lindbjerg Andersen,
- Jakob Skou Pedersen,
- Anders H. Lund
Affiliations
- Nkerorema Djodji Damas
- Biotech Research and Innovation Centre, University of Copenhagen
- Michela Marcatti
- Biotech Research and Innovation Centre, University of Copenhagen
- Christophe Côme
- Biotech Research and Innovation Centre, University of Copenhagen
- Lise Lotte Christensen
- Department for Molecular Medicine, Aarhus University Hospital
- Morten Muhlig Nielsen
- Department for Molecular Medicine, Aarhus University Hospital
- Roland Baumgartner
- Biotech Research and Innovation Centre, University of Copenhagen
- Helene Maria Gylling
- Biotech Research and Innovation Centre, University of Copenhagen
- Giulia Maglieri
- Biotech Research and Innovation Centre, University of Copenhagen
- Carsten Friis Rundsten
- Biotech Research and Innovation Centre, University of Copenhagen
- Stefan E. Seemann
- Center for Non-Coding RNA in Technology and Health, University of Copenhagen
- Nicolas Rapin
- Biotech Research and Innovation Centre, University of Copenhagen
- Simon Thézenas
- Biostatistics Unit, Institut Régional du Cancer de Montpellier (ICM)—Val d’Aurelle
- Søren Vang
- Department for Molecular Medicine, Aarhus University Hospital
- Torben Ørntoft
- Department for Molecular Medicine, Aarhus University Hospital
- Claus Lindbjerg Andersen
- Department for Molecular Medicine, Aarhus University Hospital
- Jakob Skou Pedersen
- Department for Molecular Medicine, Aarhus University Hospital
- Anders H. Lund
- Biotech Research and Innovation Centre, University of Copenhagen
- DOI
- https://doi.org/10.1038/ncomms13875
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Several lncRNAs have been linked to cancer. Here, the authors identify SNHG5 as a long non-coding RNA promoting proliferation and survival of colorectal cancer cells by protecting specific mRNAs from STAU1-mediated degradation.
