DEVELOPING A NEW HEMOGLOBIN A1C BASED EQUATION TO ESTIMATE -BLOOD GLUCOSE IN MAINTENANCE HEMODIALYSIS PATIENTS.

Abstract

HbA1c has been widely used as a clinically important assessment tool for outcome analyses related to glycemic control. However, there is no HbA1c-blood glucose equation formula specific for hemodialysis (HD) patients. In this study, we sought to develop HbA1c-blool glucose equation models for dialysis patients. We examined associations between HbA1c levels and random serum glucose levels over time in a contemporary cohort of 18,361 diabetic maintenance HD patients treated in DaVita dialysis clinics from July 2001 through June 2006 with 276,277 paired measurements of HbA1c and glucose. Time-averaged HbA1c values and blood glucose (BG) values were compared using regression models with and without adjustment for hemoglobin, albumin, patients' age, gender, and/or race/ethnicity to determine a new equation model. The new models were compared to the previously reported equations (DCCT and ADAG). modal formula adjust R2 Our modal BG=53.7+28.8*HbA1c-18.2*Alb 0.3243 DCCT BG=35.6*HbA1c-77.3 0.3141 ADAG BG=28.7*HbA1c-46.7 0.3141 In conclusion, the association between HbA1c and BG in HD patients is different from non-HD patient. Our proposed model results in better estimated BG level in HD patients compared to previously reported models.