Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution

Doo Nam Kim; Bernhard C. Thiel; Tyler Mrozowich; Scott P. Hennelly; Ivo L. Hofacker; Trushar R. Patel; Karissa Y. Sanbonmatsu

doi:10.1038/s41467-019-13942-4

Nature Communications (Jan 2020)

Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution

Doo Nam Kim,
Bernhard C. Thiel,
Tyler Mrozowich,
Scott P. Hennelly,
Ivo L. Hofacker,
Trushar R. Patel,
Karissa Y. Sanbonmatsu

Affiliations

Doo Nam Kim: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory
Bernhard C. Thiel: Department of Theoretical Chemistry, University of Vienna
Tyler Mrozowich: Alberta RNA Research & Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge
Scott P. Hennelly: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory
Ivo L. Hofacker: Department of Theoretical Chemistry, University of Vienna
Trushar R. Patel: Alberta RNA Research & Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge
Karissa Y. Sanbonmatsu: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory

DOI: https://doi.org/10.1038/s41467-019-13942-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Many RNA systems possess highly ordered 3-D structures that are essential to their function. Here the authors demonstrate that the long non-coding RNA Braveheart possesses a flexible but defined 3-D structure which is remodeled upon binding the protein CNBP.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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