Romanian Journal of Internal Medicine (Sep 2024)
A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children
- Jabandziev Petr,
- Hubacek Jaroslav Alois,
- Michalek Jaroslav,
- Jouza Martin,
- Papez Jan,
- Pecl Jakub,
- Slaba Katerina,
- Slaby Ondrej,
- Urik Milan,
- Aulicka Stefania,
- Kunovsky Lumir,
- Michalek Jaroslav,
- Dominik Petr,
- Kratochvil Milan,
- Klucka Jozef,
- Stourac Petr
Affiliations
- Jabandziev Petr
- 1Department of Pediatrics, University Hospital Brno, Černopolní 212/9, 625 00, Brno, Czech Republic
- Hubacek Jaroslav Alois
- 4Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Vídeňská 1958/9, 140 21, Prague, Czech Republic
- Michalek Jaroslav
- 6Department of Quantitative Methods, University of Defence, Kounicova 156/65, 662 10, Brno, Czech Republic
- Jouza Martin
- 1Department of Pediatrics, University Hospital Brno, Černopolní 212/9, 625 00, Brno, Czech Republic
- Papez Jan
- 1Department of Pediatrics, University Hospital Brno, Černopolní 212/9, 625 00, Brno, Czech Republic
- Pecl Jakub
- 1Department of Pediatrics, University Hospital Brno, Černopolní 212/9, 625 00, Brno, Czech Republic
- Slaba Katerina
- 1Department of Pediatrics, University Hospital Brno, Černopolní 212/9, 625 00, Brno, Czech Republic
- Slaby Ondrej
- 2Faculty of Medicine, Masaryk University, Černopolní 212/9, 625 00, Brno, Czech Republic
- Urik Milan
- 2Faculty of Medicine, Masaryk University, Černopolní 212/9, 625 00, Brno, Czech Republic
- Aulicka Stefania
- 2Faculty of Medicine, Masaryk University, Černopolní 212/9, 625 00, Brno, Czech Republic
- Kunovsky Lumir
- 7Department of Gastroenterology and Internal Medicine, University Hospital Brno, Jihlavská 340, 625 00, Brno, Czech Republic
- Michalek Jaroslav
- 9Cellthera Ltd., Vídeňská 119, 619 00, Brno, Czech Republic
- Dominik Petr
- 2Faculty of Medicine, Masaryk University, Černopolní 212/9, 625 00, Brno, Czech Republic
- Kratochvil Milan
- 2Faculty of Medicine, Masaryk University, Černopolní 212/9, 625 00, Brno, Czech Republic
- Klucka Jozef
- 2Faculty of Medicine, Masaryk University, Černopolní 212/9, 625 00, Brno, Czech Republic
- Stourac Petr
- 2Faculty of Medicine, Masaryk University, Černopolní 212/9, 625 00, Brno, Czech Republic
- DOI
- https://doi.org/10.2478/rjim-2024-0008
- Journal volume & issue
-
Vol. 62,
no. 3
pp. 279 – 285
Abstract
Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential association between a variant of the fat mass and obesity-associated (FTO) gene and risk of sepsis in children and adolescents.
Keywords
