Relationship between Serum levels of MMP-9 and late ocular complications in

Abstract

Background: Sulfur mustard (SM) is a chemical warfare agent which has been used extensively during Iran- Iraq war. One of the major late complications is ocular complications. Matrix metalloproteinases (MMPs) are a group of zinc and calciumdependent endopeptidases which play important roles in the homeostasis of extracellular matrix (ECM) and inflammatory conditions. It has been proved that MMP-9 , as a member of MMPs, is involved in many inflammatory ocular disorders. Aim: The aim of this study was to evaluate the relation between serum MMP-9 and late ocular complications of SM exposure. Methods: In this study, 72 chemical veterans with late ocular complications (case group) & 63 chemical veterans without ocular complications (control group) were selected from Sardasht via a systematic sampling. Ophthalmologic examinatia of the study group was performed by slit lamp and serum MMP-9 was measured by ELISA sandwich method. Results: The median of serum MMP-9 was 849.3pg/ml in the case group and 787.0pg/ml in the control group. There was no significant statistical difference (p=0.700). There was also no statistical relationship between serum MMP-9 and each involved ocular region. Conclusions: In many studies, It has been proved that MMP-9 expression is increased in tear fluid & culture media of conjunctival & corneal epithelial cells from patients with ocular inflammatory diseases. Therefore, assessment of MMP-9 in mentioned samples of chemical veterans with ocular complications would be valuable.

Keywords

• mmp9
• mustard gas
• chemical victims
• ocular complications
• sardasht