OncoTargets and Therapy (Feb 2020)

Significant Contribution of DNA Repair Human 8-Oxoguanine DNA N-Glycosylase 1 Genotypes to Renal Cell Carcinoma

  • Chang WS,
  • Shen TC,
  • Liao JM,
  • Tsai YT,
  • Hsia TC,
  • Wu HC,
  • Tsai CW,
  • Bau DT

Journal volume & issue
Vol. Volume 13
pp. 1583 – 1591

Abstract

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Wen-Shin Chang,1,* Te-Chun Shen,1– 3,* Jiuan-Miaw Liao,4,* Yueh-Ting Tsai,1 Te-Chun Hsia,2 Hsi-Chin Wu,1,3 Chia-Wen Tsai,1 Da-Tian Bau1,5,6 1Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan; 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; 3School of Medicine, China Medical University, Taichung, Taiwan; 4Department of Physiology, Chung Shan Medical University and Chung Shan Medical University Hospital, Taichung, Taiwan; 5Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; 6Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan*These authors contributed equally to this workCorrespondence: Da-Tian Bau; Chia-Wen TsaiTerry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, No. 2 Yude Road, Taichung 404, TaiwanTel +886-4-22052121Email [email protected]: DNA repair systems play essential roles in genomic stability and carcinogenesis. Therefore, genotypes at DNA repair loci may contribute to the determination of personal susceptibility to cancers. The contribution of human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) genotypes to renal cell carcinoma (RCC) is largely unknown. This study aimed to evaluate the contributions of hOGG1 rs1052133 genotypes to the RCC risk.Methods: We evaluated the contribution of hOGG1 rs1052133 (G/C) genotypes among 118 cases and 590 controls and analyzed the interactions of hOGG1 genotypes with smoking, alcohol drinking, hypertension, and diabetes status.Results: The hOGG1 rs1052133 CC genotype was significantly associated with a decreased RCC risk compared with that of the GG genotype (odds ratio [OR] = 0.25, 95% confidence interval [CI] = 0.09– 0.72, p = 0.0049). The frequency of the rs1052133 C allele was significantly low in the RCC group (22.5% vs 31.2%; OR = 0.64; 95% CI = 0.46– 0.89, p = 0.0074). Stratifying the analysis according to smoking, alcohol drinking, and diabetes status revealed no difference in the rs1052133 genotype distribution among these subgroups. A significant differential distribution of rs1052133 genotypes was observed among subjects with hypertension.Conclusion: The CC genotype of rs1052133 may play a role in determining RCC susceptibility among Taiwanese people and may serve as a biomarker of RCC, particularly in patients with hypertension.Keywords: hOGG1, genotype, polymorphism, renal cell carcinoma

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