Nature Communications (Apr 2021)
Monocyte progenitors give rise to multinucleated giant cells
- Anne Kathrin Lösslein,
- Florens Lohrmann,
- Lisa Scheuermann,
- Kourosh Gharun,
- Jana Neuber,
- Julia Kolter,
- Aaron James Forde,
- Christian Kleimeyer,
- Ying Yee Poh,
- Matthias Mack,
- Antigoni Triantafyllopoulou,
- Micah D. Dunlap,
- Shabaana A. Khader,
- Maximilian Seidl,
- Alexandra Hölscher,
- Christoph Hölscher,
- Xue Li Guan,
- Anca Dorhoi,
- Philipp Henneke
Affiliations
- Anne Kathrin Lösslein
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg
- Florens Lohrmann
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg
- Lisa Scheuermann
- Max Planck Institute for Infection Biology
- Kourosh Gharun
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg
- Jana Neuber
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg
- Julia Kolter
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg
- Aaron James Forde
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg
- Christian Kleimeyer
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg
- Ying Yee Poh
- Nanyang Technological University, Lee Kong Chian School of Medicine
- Matthias Mack
- University Hospital Regensburg, Internal Medicine II, Nephrology
- Antigoni Triantafyllopoulou
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg
- Micah D. Dunlap
- Department of Molecular Microbiology, Washington University in St. Louis School of Medicine
- Shabaana A. Khader
- Department of Molecular Microbiology, Washington University in St. Louis School of Medicine
- Maximilian Seidl
- Center for Chronic Immunodeficiency and Institute for Clinical Pathology, Department of Pathology, Medical Center and Faculty of Medicine, Freiburg, Germany and Institute of Pathology, Heinrich Heine University and University Hospital of Duesseldorf
- Alexandra Hölscher
- Forschungszentrum Borstel, Leibniz Lungenzentrum
- Christoph Hölscher
- Forschungszentrum Borstel, Leibniz Lungenzentrum
- Xue Li Guan
- Nanyang Technological University, Lee Kong Chian School of Medicine
- Anca Dorhoi
- Max Planck Institute for Infection Biology
- Philipp Henneke
- Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-021-22103-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.
