Difference of genetic polymorphisms in patients with type 2 diabetes mellitus with absence or presence of chronic heart failure with preserved ejection fraction

Abstract

Background. It is important to note a close comorbidity of type 2 diabetes mellitus (DM2) and cardiovascular issues, in particular, chronic heart failure (CHF) among the elderly patients. Research of predisposing genes’ polymorphisms allows to connect genotype particularities with the development of such conditions. Aim. Identify genetic polymorphisms in patients with DM2 and CHF with preserved ejection fraction. Materials and methods. Polymorphisms of genes of folate cycle, metabolism, hemostasis, neurohumoral status were studied in 106 patients (age 69.7±10.1 years) with DM2 and hypertension with and without CHF. Results. In patients with DM2 without CHF, the frequency of polymorphisms of these genes is comparable to the population. There are MTHFR: 677 CT, MTR: A2756G, ITGB3: T1565C, PAI-1: -675 5G4G, NOS3: -786 TC, PPARG: C1431T was found in patients with DM2 and CHF, a statistically significant increase in the frequency of gene polymorphisms was found, compared with patients with DM2 without CHF. Conclusion. The identified polymorphisms in patients with type 2 diabetes and CHF with preserved LV ejection fraction are associated with such phenotypic manifestations as: a tendency to thrombophilia, realized through a violation of homocysteine, vascular tone and trophism, immune response, as well as the oxidation of free fatty acids and the activation of the inflammation process.

Keywords

• chronic heart failure
• type 2 diabetes mellitus
• ejection fraction
• genetic polymorphisms