Prognostic and Immunological Role of <i>STK38</i> across Cancers: Friend or Foe?

Yankuo Liu; Zhiyuan Shi; Zeyuan Zheng; Jinxin Li; Kunao Yang; Chunlan Xu; Qing Liu; Zhicheng Gong; Yi Yang; Yue Zhao; Zuodong Xuan; Huimin Sun; Chen Shao

doi:10.3390/ijms231911590

International Journal of Molecular Sciences (Sep 2022)

Prognostic and Immunological Role of <i>STK38</i> across Cancers: Friend or Foe?

Yankuo Liu,
Zhiyuan Shi,
Zeyuan Zheng,
Jinxin Li,
Kunao Yang,
Chunlan Xu,
Qing Liu,
Zhicheng Gong,
Yi Yang,
Yue Zhao,
Zuodong Xuan,
Huimin Sun,
Chen Shao

Affiliations

Yankuo Liu: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Zhiyuan Shi: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Zeyuan Zheng: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Jinxin Li: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Kunao Yang: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Chunlan Xu: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Qing Liu: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Zhicheng Gong: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Yi Yang: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Yue Zhao: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Zuodong Xuan: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Huimin Sun: Central Laboratory, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China
Chen Shao: Department of Urology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China

DOI: https://doi.org/10.3390/ijms231911590
Journal volume & issue: Vol. 23, no. 19
p. 11590

Abstract

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Although STK38 (serine-threonine kinase 38) has been proven to play an important role in cancer initiation and progression based on a series of cell and animal experiments, no systemic assessment of STK38 across human cancers is available. We firstly performed a pan-cancer analysis of STK38 in this study. The expression level of STK38 was significantly different between tumor and normal tissues in 15 types of cancers. Meanwhile, a prognosis analysis showed that a distinct relationship existed between STK38 expression and the clinical prognosis of cancer patients. Furthermore, the expression of STK38 was related to the infiltration of immune cells, such as NK cells, memory CD4+ T cells, mast cells and cancer-associated fibroblasts in a few cancers. There were three immune-associated signaling pathways involved in KEGG analysis of STK38. In general, STK38 shows a significant prognostic value in different cancers and is closely associated with cancer immunity.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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