Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations

Nele Vandersickel; Enid Van Nieuwenhuyse; Gunnar Seemann; Gunnar Seemann; Alexander V. Panfilov

doi:10.3389/fphys.2017.00404

Frontiers in Physiology (Jun 2017)

Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations

Nele Vandersickel,
Enid Van Nieuwenhuyse,
Gunnar Seemann,
Gunnar Seemann,
Alexander V. Panfilov

Affiliations

Nele Vandersickel: Department of Physics and Astronomy, Ghent UniversityGhent, Belgium
Enid Van Nieuwenhuyse: Department of Physics and Astronomy, Ghent UniversityGhent, Belgium
Gunnar Seemann: Institute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, Medical Center, University of FreiburgFreiburg, Germany
Gunnar Seemann: Faculty of Medicine, University of FreiburgFreiburg, Germany
Alexander V. Panfilov: Department of Physics and Astronomy, Ghent UniversityGhent, Belgium

DOI: https://doi.org/10.3389/fphys.2017.00404
Journal volume & issue: Vol. 8

Abstract

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Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we present an overview of the relevant computational studies on spatial EAD dynamics in 1D, 2D, and in 3D anatomical models and discuss the relation of EADs to cardiac arrhythmias. We also discuss unsolved problems and highlight new lines of research in this area.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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