Effective utilization of basic nature of WEB in copper catalyzed Chan-Lam N-arylation reaction under ligand free conditions

Abstract

A mild and green protocol has been developed for a copper catalyzed N-arylation of anilines and imidazoles under external base/additive, promoter and ligand free conditions. The main advantage of this work is that agro waste WEB (Water Extract of Banana Peel Ash) has emerged as solvent as well as base. The reaction protocol avoids hazardous solvents, toxic chemicals, ligands etc. Interestingly addition of alcoholic co-solvent enhanced the yield of the product.

Keywords

• Cross-coupling
• N-arylation
• WEB
• Sustainable