Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach

Jimin Min; Paige N. Vega; Amy C. Engevik; Janice A. Williams; Qing Yang; Loraine M. Patterson; Alan J. Simmons; R. Jarrett Bliton; Joshua W. Betts; Ken S. Lau; Scott T. Magness; James R. Goldenring; Eunyoung Choi

doi:10.1038/s41467-019-13479-6

Nature Communications (Dec 2019)

Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach

Jimin Min,
Paige N. Vega,
Amy C. Engevik,
Janice A. Williams,
Qing Yang,
Loraine M. Patterson,
Alan J. Simmons,
R. Jarrett Bliton,
Joshua W. Betts,
Ken S. Lau,
Scott T. Magness,
James R. Goldenring,
Eunyoung Choi

Affiliations

Jimin Min: Department of Surgery, Vanderbilt University School of Medicine
Paige N. Vega: Epithelial Biology Center, Vanderbilt University School of Medicine
Amy C. Engevik: Department of Surgery, Vanderbilt University School of Medicine
Janice A. Williams: Cell Imaging Share Resource, Vanderbilt University School of Medicine
Qing Yang: Department of Surgery, Vanderbilt University School of Medicine
Loraine M. Patterson: Center for GI Biology and Disease, University of North Carolina at Chapel Hill
Alan J. Simmons: Epithelial Biology Center, Vanderbilt University School of Medicine
R. Jarrett Bliton: UNC Departments of Cell Biology and Physiology, University of North Carolina at Chapel Hill
Joshua W. Betts: Epithelial Biology Center, Vanderbilt University School of Medicine
Ken S. Lau: Epithelial Biology Center, Vanderbilt University School of Medicine
Scott T. Magness: Center for GI Biology and Disease, University of North Carolina at Chapel Hill
James R. Goldenring: Department of Surgery, Vanderbilt University School of Medicine
Eunyoung Choi: Department of Surgery, Vanderbilt University School of Medicine

DOI: https://doi.org/10.1038/s41467-019-13479-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

Read online

How a precancerous form (dysplasia) becomes gastric cancer is unclear. Here, the authors assess the role of Kras activation in heterogenous dysplastic cells in murine stomach corpus organoids, identifying two dysplastic stem cell populations and show that MEK inhibition causes alterations in cell behavior.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal